| Leptin leapt into the headlines when it
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| | fat people might also lack leptin, and
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| was identified in 1995 as a protein that
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| | that it could make them lose weight. But
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| triggers weight loss in mice. Leptin (the
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| | it was not so. Scientists found that most
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| Greek term for thin) is a hormone
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| | fat people had lots of leptin, and giving
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| released by your fat cells. When you lose
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| | them more had little effect. (The New
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| fat, leptin levels drop and when you gain
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| | York Times 26/11/2002).
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| fat, leptin levels rise.
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| | Researchers at the Oregon National
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| Recent research into leptin has revealed
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| | Primate Research Center conducted a study
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| what is likely to be very important in
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| | in mice involving two separate groups
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| the control of appetite, weight loss and
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| | that were fed high-fat and low-fat diets.
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| the regulation of body weight. Advances
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| | The high-fat diet group developed
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| in leptin research and its role in the
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| | symptoms of diabetes and obesity while
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| control of obesity would lead to
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| | the low-fat diet group did not. The
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| reductions in diabetes, coronary heart
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| | researchers tested cells which conduct
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| disease and many forms of cancer, all of
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| | nerve impulses and found the cells
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| which are increased in obesity.
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| | behaved as if there was no leptin
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| American adults are overweight and more
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| | present, even though levels were 40-times
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| than 30 percent are obese. Currently 50
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| | higher than in normal mice. (Cell Metab.
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| million Americans suffer from metabolic
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| | 2007 Mar;5(3):181-94).
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| syndrome - a disease associated with
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| | This is due to obese people becoming
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| obesity and encompassing coronary artery
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| | resistant to leptin's signal. When the
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| disease and type 2 diabetes.
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| | brain fails to sense the leptin hormone's
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| Leptin affects our weight and our
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| | signal correctly it thinks that more fat
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| appetites. Levels of leptin rise just
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| | is required, even though we have enough,
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| before a meal and fall when people are
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| | and fat begins to accumulate while
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| full. It is now known that leptin not
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| | metabolism slows down. Some scientists
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| only can affect the chemical responses
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| | think that either leptin is not
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| that affect how hungry you are but also
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| | transported through the blood-brain
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| can affect the wiring of your brain.
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| | barrier properly or the brain is not
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| Scientists are interested in whether
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| | interpreting the signals properly.
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| leptin may be manipulated to help people,
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| | With the regular discovery of hormones
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| especially overweight people, to lose
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| | involved in regulating body weight it is
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| weight and not put it back on. They know
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| | a diverse and rapidly expanding field.
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| that leptin is released by fat cells and
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| | My own research of the literature has
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| tells the brain how much fat is on the
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| | revealed to me some dietary factors that
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| body. Once leptin has been secreted by
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| | block leptin from crossing the
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| your fat cells, it travels to the
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| | blood-brain barrier and interfere with
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| hypothalamus. This is the part of your
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| | leptin signaling. In addition, there are
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| brain that controls eating behavior.
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| | foods/methods that correct these
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| Defects in leptin signaling leads to
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| | problems. I will discuss these issues in
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| obesity, overeating, and decreased energy
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| | due course.
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| output.
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| | If this article is reproduced please
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| Normally, when leptin levels in the blood
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| | ensure the link to my website is kept
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| go up, the brain signals us to stop
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| | live. If you can't see the links hover
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| eating. But since obesity isn't the
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| | your mouse over the words in the bio box.
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| result of a lack of leptin, it is a lack
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| | References
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| of response to leptin, and obese
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| | Enriori PJ, Evans AE, Sinnayah P, Jobst
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| individuals tend to have more and larger
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| | EE, Tonelli-Lemos L, Billes SK, Glavas
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| leptin-producing fat cells than thinner
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| | MM, Grayson BE, Perello M, Nillni EA,
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| people, their leptin levels increase
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| | Grove KL, Cowley MA. Diet-induced obesity
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| substantially with every pound of
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| | causes severe but reversible leptin
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| additional weight gain. This is
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| | resistance in arcuate melanocortin
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| illustrated below.
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| | neurons. Cell Metab. 2007
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| Mice lacking leptin ate voraciously and
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| | Mar;5(3):181-94.
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| grew enormously fat; leptin injections
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| | If this article is reproduced please
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| made them stop eating and slim down. The
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| | ensure the link to my website is kept
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| discovery led researchers to think that
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| | live.
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