| Gilbert's syndrome is a harmless condition | | | | |
| but often causes anxiety before the condition | | | | Mutation in the UDP-glucuronosyltransferase |
| is diagnosed. It is arguably the most common | | | | gene. |
| medical syndrome identified.Gilbert's | | | | |
| Syndrome is detected by finding a slightly | | | | Fasting: This produces an increase in the |
| raised bilirubin level in the blood with no | | | | plasma unconjugated bilirubin level. |
| other abnormalities of liver function and no | | | | |
| signs of liver disease. It is the most common | | | | Stress, such as trauma and overexertion. |
| hereditary cause of increased bilirubin, and | | | | |
| is found in up to 5% of the population. | | | | Menstrual periods. |
| Unconjugated hyperbilirubinemia in Gilbert | | | | |
| syndrome has long been recognized as due to | | | | Intercurrent illness, such as a viral |
| underactivity of the conjugating enzyme | | | | infection. |
| system bilirubin-uridine diphosphate | | | | |
| glucuronyl transferase. The main symptom is | | | | Symptoms of Gilbert's syndrome |
| otherwise harmless jaundice which does not | | | | |
| require treatment, caused by elevated levels | | | | Some sign and symptoms related to Gilbert's |
| of unconjugated bilirubin in the bloodstream. | | | | syndrome are as follows: |
| Also known as constitutional hepatic | | | | |
| dysfunction, unconjugated benign | | | | Gilbert's Syndrome is generally harmless and |
| bilirubinemia and familial nonhemolytic | | | | does not produce any symptoms, although some |
| jaundice, Gilbert's syndrome typically | | | | sufferers complain of excessive fatigue. |
| doesn't require treatment or pose serious | | | | |
| complications. Bilirubin levels tend | | | | Mild jaundice (yellowing of skin and whites |
| particularly to be increased in Gilbert | | | | of eyes). |
| syndrome with starvation or dehydration. | | | | |
| | | | Loss of appetite. |
| Gilbert's syndrome is most often recognised | | | | |
| in the second or third decade of life and is | | | | Pain in the abdomen (uncommon). |
| rarely diagnosed before puberty. Men are | | | | |
| often affected more than women. It can also | | | | Weakness. |
| frequently coexist with the conditions | | | | |
| associated with unconjugated | | | | Treatment of Gilbert's syndrome |
| hyperbilirubinemia, such as thalassemia and | | | | |
| glucose-6-phosphate deficiency. Gilbert's is | | | | Here is list of the methods for treating |
| often diagnosed in the late teens and early | | | | Gilbert's syndrome: |
| twenties. The condition is inherited and is | | | | |
| relatively common being estimated to affect | | | | Gilbert's syndrome seems to be a lifelong |
| about 1 person in 20. The source of this | | | | disorder, but it usually doesn't need medical |
| hyperbilirubinemia is reduced activity of the | | | | treatment. |
| enzyme (glucuronyl transferase) which | | | | |
| conjugates bilirubin and some other | | | | Medication that helps the enzyme work better |
| lipophilic molecules. In people with | | | | may be used to treat the jaundice if it |
| Gilbert's syndrome, the bilirubin level often | | | | becomes a problem. |
| goes up and down. At times, it may be within | | | | |
| the normal range. People with Gilbert's | | | | Phenobarbitone in small doses can sometimes |
| syndrome have an inherited abnormality that | | | | help clear the jaundice. |
| causes reduced production of an enzyme | | | | |
| involved in processing bilirubin. It is often | | | | People with Gilbert's syndrome don't |
| first diagnosed in the late teens or early | | | | typically need long-term monitoring of their |
| twenties. | | | | condition or repeat blood tests. |
| | | | |
| Causes of Gilbert's syndrome | | | | If you're distressed by jaundice, the |
| | | | barbiturate medication phenobarbital may |
| The common causes and risk factor's of | | | | reduce bilirubin levels. |
| Gilbert's syndrome include the following: | | | | |