| Lynch syndrome is a rare disorder. The | | | | |
| condition is named after Henry Lynch, a | | | | If you have a family history of Lynch |
| doctor and authority on inherited cancers. | | | | syndrome, you're at much greater risk of |
| The estimated proportion of all CRCs that are | | | | inheriting this condition yourself. |
| caused by Lynch syndrome depends on how this | | | | |
| syndrome is defined, with traditional | | | | Daily alcohol use (may double the risk). |
| definitions being based on family history and | | | | |
| age of onset. It is also known as hereditary | | | | Eating a high-fat, low-fiber diet. |
| nonpolyposis colorectal cancer | | | | |
| syndrome(HNPCC). It is caused by mutations or | | | | Genetic disorders such as familial polyposis |
| alterations of particular genes. Lynch | | | | syndromes and hereditary non-polyposis colon |
| syndrome strongly predisposes people who have | | | | cancer syndrome (HNPCC). |
| this inherited defect to develop colorectal | | | | |
| cancer as well as several other types of | | | | Not having periods, or not having them often. |
| cancer. The genes associated with HNPCC can | | | | |
| sometimes cause other cancers, such as | | | | Smoking is also a risk factor for Lynch |
| stomach, ovary, endometrium (the lining of | | | | syndrome. |
| the womb) and kidney. HNPCC is an inherited | | | | |
| cause of cancer of the bowel. The HNPCC | | | | Symptoms of Lynch syndrome |
| syndrome is due to mutation in a gene in the | | | | |
| DNA mismatch repair system, usually the MLH1 | | | | Some sign and symptoms related to Lynch |
| or MSH2 gene or less often the MSH6 or PMS2 | | | | syndrome are as follows: |
| genes. The syndrome is classified as Type I | | | | |
| in the absence of extracolonic cancers and | | | | Changes in bowel habits- for example, |
| Type II if these are present. However, | | | | constipation or diarrhea that persists for |
| sarcomas have rarely been described in these | | | | longer than several days. |
| families. The cancers of the colorectal area | | | | |
| associated with the Lynch Syndromes usually | | | | Change in appetite. |
| develop at a younger age than is normally | | | | |
| found in other persons with colorectal | | | | Abdominal pain and even an abdominal mass. |
| cancer. | | | | |
| | | | Feelings of fatigue or weakness. |
| The syndrome is neither common nor rare, | | | | |
| occurring in one or two of every 1,000 | | | | Black, tarry stool, which may represent |
| people. Women with HNPCC have a 20-60% | | | | bleeding above the rectum. |
| lifetime risk of endometrial cancer. In | | | | |
| HNPCC, the gastric cancer is usually | | | | Iron deficiency without another identifiable |
| intestinal-type adenocarcinoma. Other | | | | cause. |
| HNPCC-related cancers have characteristic | | | | |
| features: the urinary tract cancers are | | | | Rectal bleeding. |
| transitional carcinoma of the ureter and | | | | |
| renal pelvis; the small bowel cancer is most | | | | Fatigue associated with anemia. |
| common in the duodenum and jejunum; and the | | | | |
| most common type of brain tumor is | | | | Treatment of Lynch syndrome |
| glioblastoma. When colorectal cancer is | | | | |
| associated with Lynch syndrome, it tends to | | | | Here is list of the methods for treating |
| occur at a younger age than in most other | | | | Lynch Syndrome: |
| colorectal cancer cases. Colorectal cancer | | | | |
| associated with Lynch syndrome tends to occur | | | | When polyps associated with Lynch syndrome |
| in people at a younger age than for people | | | | are present, doctors remove them during a |
| with the more common nonhereditary forms of | | | | colonoscopy. |
| colorectal cancer. Family history can provide | | | | |
| important clues to the presence of the Lynch | | | | Chemotherapy, which uses drugs to destroy |
| syndrome. Different segments of the DNA | | | | cancer cells. This approach often follows |
| strands contain genes responsible for | | | | surgery. |
| different structures and functions in the | | | | |
| body. For example, certain segments of DNA | | | | Surgery may also be an option in people who |
| carry genes that determine one's eye color, | | | | carry the genetic mutation of Lynch syndrome, |
| hair color, height, and other physical | | | | even if they don't yet have colorectal |
| characteristics. Other DNA segments of DNA | | | | cancer. |
| carry genes that regulate the duplication and | | | | |
| the rate of growth of cells. | | | | The standard treatment is to give |
| | | | radiotherapy after surgery to women in |
| Causes of Lynch syndrome | | | | certain circumstances. |
| | | | |
| The common causes and risk factor's of Lynch | | | | Most people with Lynch syndrome choose |
| syndrome include the following: | | | | frequent colonoscopies over prophylactic |
| | | | surgery. |
| Lynch syndrome is caused by mutations or | | | | |
| alterations of particular genes. | | | | Juliet Cohen writes articles for diseases |
| | | | cure and health care information. |
| Age is the primary risk factor. | | | | |