| Lynch syndrome is a rare disorder. The
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| | physical characteristics. Other DNA
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| condition is named after Henry Lynch, a
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| | segments of DNA carry genes that regulate
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| doctor and authority on inherited
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| | the duplication and the rate of growth of
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| cancers. The estimated proportion of all
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| | cells.
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| CRCs that are caused by Lynch syndrome
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| | Causes of Lynch syndrome
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| depends on how this syndrome is defined,
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| | The common causes and risk factor's of
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| with traditional definitions being based
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| | Lynch syndrome include the following:
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| on family history and age of onset. It is
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| | Lynch syndrome is caused by mutations or
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| also known as hereditary nonpolyposis
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| | alterations of particular genes.
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| colorectal cancer syndrome(HNPCC). It is
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| | Age is the primary risk factor.
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| caused by mutations or alterations of
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| | If you have a family history of Lynch
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| particular genes. Lynch syndrome strongly
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| | syndrome, you're at much greater risk of
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| predisposes people who have this
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| | inheriting this condition yourself.
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| inherited defect to develop colorectal
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| | Daily alcohol use (may double the risk).
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| cancer as well as several other types of
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| | Eating a high-fat, low-fiber diet.
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| cancer. The genes associated with HNPCC
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| | Genetic disorders such as familial
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| can sometimes cause other cancers, such
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| | polyposis syndromes and hereditary
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| as stomach, ovary, endometrium (the
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| | non-polyposis colon cancer syndrome
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| lining of the womb) and kidney. HNPCC is
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| | (HNPCC).
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| an inherited cause of cancer of the
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| | Not having periods, or not having them
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| bowel. The HNPCC syndrome is due to
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| | often.
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| mutation in a gene in the DNA mismatch
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| | Smoking is also a risk factor for Lynch
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| repair system, usually the MLH1 or MSH2
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| | syndrome.
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| gene or less often the MSH6 or PMS2
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| | Symptoms of Lynch syndrome
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| genes. The syndrome is classified as Type
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| | Some sign and symptoms related to Lynch
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| I in the absence of extracolonic cancers
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| | syndrome are as follows:
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| and Type II if these are present.
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| | Changes in bowel habits- for example,
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| However, sarcomas have rarely been
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| | constipation or diarrhea that persists
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| described in these families. The cancers
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| | for longer than several days.
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| of the colorectal area associated with
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| | Change in appetite.
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| the Lynch Syndromes usually develop at a
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| | Abdominal pain and even an abdominal
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| younger age than is normally found in
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| | mass.
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| other persons with colorectal cancer.
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| | Feelings of fatigue or weakness.
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| The syndrome is neither common nor rare,
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| | Black, tarry stool, which may represent
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| occurring in one or two of every 1,000
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| | bleeding above the rectum.
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| people. Women with HNPCC have a 20-60%
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| | Iron deficiency without another
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| lifetime risk of endometrial cancer. In
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| | identifiable cause.
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| HNPCC, the gastric cancer is usually
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| | Rectal bleeding.
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| intestinal-type adenocarcinoma. Other
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| | Fatigue associated with anemia.
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| HNPCC-related cancers have characteristic
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| | Treatment of Lynch syndrome
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| features: the urinary tract cancers are
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| | Here is list of the methods for treating
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| transitional carcinoma of the ureter and
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| | Lynch Syndrome:
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| renal pelvis; the small bowel cancer is
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| | When polyps associated with Lynch
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| most common in the duodenum and jejunum;
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| | syndrome are present, doctors remove them
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| and the most common type of brain tumor
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| | during a colonoscopy.
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| is glioblastoma. When colorectal cancer
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| | Chemotherapy, which uses drugs to destroy
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| is associated with Lynch syndrome, it
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| | cancer cells. This approach often follows
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| tends to occur at a younger age than in
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| | surgery.
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| most other colorectal cancer cases.
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| | Surgery may also be an option in people
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| Colorectal cancer associated with Lynch
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| | who carry the genetic mutation of Lynch
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| syndrome tends to occur in people at a
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| | syndrome, even if they don't yet have
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| younger age than for people with the more
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| | colorectal cancer.
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| common nonhereditary forms of colorectal
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| | The standard treatment is to give
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| cancer. Family history can provide
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| | radiotherapy after surgery to women in
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| important clues to the presence of the
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| | certain circumstances.
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| Lynch syndrome. Different segments of the
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| | Most people with Lynch syndrome choose
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| DNA strands contain genes responsible for
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| | frequent colonoscopies over prophylactic
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| different structures and functions in the
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| | surgery.
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| body. For example, certain segments of
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| | Juliet Cohen writes articles for diseases
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| DNA carry genes that determine one's eye
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| | cure and health care information.
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| color, hair color, height, and other
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