| Lynch syndrome is a rare disorder. The condition is | | | | color, height, and other physical characteristics. Other |
| named after Henry Lynch, a doctor and authority on | | | | DNA segments of DNA carry genes that regulate the |
| inherited cancers. The estimated proportion of all | | | | duplication and the rate of growth of cells. |
| CRCs that are caused by Lynch syndrome depends | | | | Causes of Lynch syndrome |
| on how this syndrome is defined, with traditional | | | | The common causes and risk factor's of Lynch |
| definitions being based on family history and age of | | | | syndrome include the following: |
| onset. It is also known as hereditary nonpolyposis | | | | Lynch syndrome is caused by mutations or |
| colorectal cancer syndrome(HNPCC). It is caused by | | | | alterations of particular genes. |
| mutations or alterations of particular genes. Lynch | | | | Age is the primary risk factor. |
| syndrome strongly predisposes people who have this | | | | If you have a family history of Lynch syndrome, |
| inherited defect to develop colorectal cancer as well | | | | you're at much greater risk of inheriting this condition |
| as several other types of cancer. The genes | | | | yourself. |
| associated with HNPCC can sometimes cause other | | | | Daily alcohol use (may double the risk). |
| cancers, such as stomach, ovary, endometrium (the | | | | Eating a high-fat, low-fiber diet. |
| lining of the womb) and kidney. HNPCC is an inherited | | | | Genetic disorders such as familial polyposis syndromes |
| cause of cancer of the bowel. The HNPCC syndrome | | | | and hereditary non-polyposis colon cancer syndrome |
| is due to mutation in a gene in the DNA mismatch | | | | (HNPCC). |
| repair system, usually the MLH1 or MSH2 gene or less | | | | Not having periods, or not having them often. |
| often the MSH6 or PMS2 genes. The syndrome is | | | | Smoking is also a risk factor for Lynch syndrome. |
| classified as Type I in the absence of extracolonic | | | | Symptoms of Lynch syndrome |
| cancers and Type II if these are present. However, | | | | Some sign and symptoms related to Lynch syndrome |
| sarcomas have rarely been described in these | | | | are as follows: |
| families. The cancers of the colorectal area | | | | Changes in bowel habits- for example, constipation or |
| associated with the Lynch Syndromes usually develop | | | | diarrhea that persists for longer than several days. |
| at a younger age than is normally found in other | | | | Change in appetite. |
| persons with colorectal cancer. | | | | Abdominal pain and even an abdominal mass. |
| The syndrome is neither common nor rare, occurring | | | | Feelings of fatigue or weakness. |
| in one or two of every 1,000 people. Women with | | | | Black, tarry stool, which may represent bleeding |
| HNPCC have a 20-60% lifetime risk of endometrial | | | | above the rectum. |
| cancer. In HNPCC, the gastric cancer is usually | | | | Iron deficiency without another identifiable cause. |
| intestinal-type adenocarcinoma. Other HNPCC-related | | | | Rectal bleeding. |
| cancers have characteristic features: the urinary tract | | | | Fatigue associated with anemia. |
| cancers are transitional carcinoma of the ureter and | | | | Treatment of Lynch syndrome |
| renal pelvis; the small bowel cancer is most common | | | | Here is list of the methods for treating Lynch |
| in the duodenum and jejunum; and the most | | | | Syndrome: |
| common type of brain tumor is glioblastoma. When | | | | When polyps associated with Lynch syndrome are |
| colorectal cancer is associated with Lynch syndrome, | | | | present, doctors remove them during a colonoscopy. |
| it tends to occur at a younger age than in most | | | | Chemotherapy, which uses drugs to destroy cancer |
| other colorectal cancer cases. Colorectal cancer | | | | cells. This approach often follows surgery. |
| associated with Lynch syndrome tends to occur in | | | | Surgery may also be an option in people who carry |
| people at a younger age than for people with the | | | | the genetic mutation of Lynch syndrome, even if |
| more common nonhereditary forms of colorectal | | | | they don't yet have colorectal cancer. |
| cancer. Family history can provide important clues to | | | | The standard treatment is to give radiotherapy after |
| the presence of the Lynch syndrome. Different | | | | surgery to women in certain circumstances. |
| segments of the DNA strands contain genes | | | | Most people with Lynch syndrome choose frequent |
| responsible for different structures and functions in | | | | colonoscopies over prophylactic surgery. |
| the body. For example, certain segments of DNA | | | | Juliet Cohen writes articles for diseases cure and |
| carry genes that determine one's eye color, hair | | | | health care information. |