| Diffuse brain damage underlies akinetic | | | | Olfactory groove meningioma. |
| mutism in patients with Creutzfeldt-Jakob | | | | |
| disease. It can also occur in a stroke that | | | | Bilateral infiltration of the fornix. |
| affects both anterior cerebral territories. | | | | |
| Other locations for lesions producing | | | | Environmental.factors |
| akinetic mutism include the thalami, globus | | | | |
| pallidus, internal capsule, and frontal white | | | | Biological.factors |
| matter. These lesions are thought to disrupt | | | | |
| anterior frontal subcortical circuits that | | | | Interpersonal factors |
| subserve motivation. In our patient, the | | | | |
| syndrome of akinetic mutism appears to be the | | | | Anxiety. |
| result of a lesion in the body of the | | | | |
| cingulate gyrus in one hemisphere in | | | | Signs and Symptoms of Akinetic Mutism |
| combination with the extension of the stroke | | | | |
| into the body of the corpus callosum, | | | | Common Sign and Symptoms of Akinetic Mutism |
| effectively disconnecting the functional | | | | |
| contralateral cingulate gyrus. In effect, | | | | Whispering speech. |
| this unilateral lesion disrupted bilateral | | | | |
| pathways that are necessary in order to | | | | Demetia. |
| sustain normal motivation. The involvement of | | | | |
| bilateral callosal fibers in the regions of | | | | Ataxia. |
| the anterior cingulate may also explain the | | | | |
| profound hemineglect that emerged as the | | | | Behavioral disturbance. |
| akinetic mutism improved. The anterior | | | | |
| cingulate cortex is part of a bihemispheric | | | | Seizures. |
| network of cortical, subcortical, and white | | | | |
| matter structures that are involved in | | | | Treatment for Akinetic Mutism |
| attention, including spatial attention. The | | | | |
| left cingulate lesion and callosal | | | | Common Treatment of Akinetic Mutism |
| disconnection may have sufficiently disrupted | | | | |
| the patient's spatial attention network such | | | | Treatment of akinetic mutism with |
| that right visual neglect and anosognosia | | | | bromocriptine. |
| resulted. | | | | |
| | | | Behavior modification therapy is also helpful |
| Causes of Akinetic Mutism | | | | for akinetic mutism. |
| | | | |
| Common Causes and Risk factors of Akinetic | | | | Antidepressant medication such as , |
| Mutism: | | | | amphotericin B and zolpidem. |
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